At . Office of Response and Restoration, Benzyl butyl phthalate (BzBP) Mono benzyl phthalate (MBzP) Diisononyl phthalate (DINP) Mono isononyl phthalate (MINP) Mono(carboxyisooctyl) phthalate (MCIOP) Mono(oxoisononyl) phthalate (MOINP) Mono(hydroxyisononyl) phthalate (MHINP) Di-n-octyl phthalate (DOP) Di-n-butyl phthalate (DBP/DnBP) Carter D.E. Although slightly higher levels of BBP metabolites were found in their urine. Benzyl butylphthalate. However, numerous studies have been conducted with animals. Note: The butyl benzyl phthalate (bbp) (re)assessment has been discontinued. Although animal investigations have suggested an association between phthalate exposure and hepatocellular carcinoma, the mechanisms are unknown. 7 (1985) 213-232. Chemical Selected by OEHHA for Consideration for Listing by the Carcinogen Identification Committee and Request for Relevant Information on the Carcinogenic Hazards of Butyl Benzyl Phthalate. [ebook] Stuttgart: United Nations Environment Programme, the International Labour Organisation, and the World Health Organisation, p.9. End application include PVC floorings and wall coverings, expanded leather, PVC foams, films, sealing and adhesive systems based on polyurethane or polysulphide, PVAc based adhesives and paint binders. Long-term BBP exposure in rats leads to reduced body weight, increased weight of the liver and kidneys and carcinogenicity. [10] However, monoester metabolites of BBP (such as monophthalate) have a longer half-life of 6 hours.[7]. [32], According to EU Council Directive 67/548/EEC1, BBP is classified as reproductive toxicant and therefore restricted in use. It is considered a toxicant. Alternatively, BBP can enter food via food packaging materials. Share sensitive information only on official, secure websites. UN NO. pronouncekiwi - How To Pronounce Benzyl . Relatively little is known about the modes of action of BBP. E01 - Animal Removal Summary By Treatment Group. The metabolites of BBP are excreted rapidly, 90% of them has left the body within 24 hours. Gledhill et al. In this book, investigators from the scientific and regulatory communities describe recent technical developments in risk assessment embracing toxicology and its allied sciences, risk qualification and characterisation, risk management, and ... [15][23][26] In male rats the incidence of pancreatic tumors increased while in female rats the incidence for both pancreatic and bladder tumors increased. BBP can also be taken up orally. The objectives of the present study were to explore the benzyl butyl phthalate (BBP) and dimethyl phthalate (DMP) degradation potential of Bacillus marisflavi RR014 isolated from the tap water of public toilet and also to optimize the phthalates degradation process using response surface methodology. Gut esterases metabolize BBP to monoester metabolites. The environmental fate of butyl benzyl phthalate (BBP) was studied in two types of laboratory freshwater microcosms: (1) static single-dose ecocore microcosms designed to simulate fate processes in a lake and (2) renewal multiple-dose ... BBP is hydrolyzed under either acidic or basic conditions. Butyl benzyl phthalate had half-lives of 1.5 and 0.32 days in river die-away tests with a starting concentration of 1 mg/L and 1 ug/L, and a half-life of 1.4 days using a lake microcosm(5). The longer the alkyl chain the less soluble and the less well it is degenerated. 02/2015. During developmental phases of bone remodelling, high environmental exposure of BBP might therefore pose a problem. Available at: Just, A. C., Whyatt, R. M., Perzanowski, M. S., Calafat, A. M., & Perera, F. P. (2012)Prenatal Exposure to Butylbenzyl Phthalate and Early Eczema in an Urban Cohort. PVC flooring has been linked to a significant increase in the risk of bronchial obstruction in the first two years of life[15] and in the development of language delay in pre-school aged children. 4,800 or more. Sign in to disable ALL ads. [14] Moreover, children may be exposed to BBP by mouthing of toys. It is available in multiple type of packaging. The amount of carboxylic functional groups per molecule are relatively high (2 carboxylic functional groups with a molecular weight of 312.36). [19] BBP has also been positively associated with airway inflammation in children living in urban areas. Slightly soluble in water and slightly denser than water. Benzyl-butylester kyseliny ftalove [Czech] BRN 2062204. Benzylbutylphthalate (BBzP), hay còn gọi là n-butyl benzyl phthalate (BBP) hoặc benzyl butyl phthalate, là một loại phthalate, một loại ester của axit phthalic, cồn benzin và n-butan.Nó có nhiều loại tên thương mại khác nhau như: Palatinol BB, Unimoll BB, Sicol 160, hoặc Santicizer 160. For these organisms, the toxic effect correlates with the water solubility of the phthalate which is relatively high for BBP compared to high molecular weight phthalates. First of all, it can be taken up dermally, meaning that the compound is absorbed by the skin. The amount of the compound that is being absorbed by the body depends on the dose that has been administered. Belongs to the Following Reactive Group(s), Protective gloves and goggles (USCG, 1999). Product Name Benzyl butyl phthalate Product Code SC-239317 Recommended use of the chemical and restrictions on use For research use only. • butyl benzyl phthalate (BBP) • di-n-octyl phthalate (DnOP) • di-n-hexyl phthalate (DnHP) Phthalates are a group of similar chemicals widely used to soften and increase the flex-ibility of plastic consumer products such as shower curtains, medical devices, upholstery, ChemicalBull has been Benzyl Butyl Phthalate (Cas 85-68-7) leading supplier in India. Benzyl butyl phthalate (BBP) is a widely used plasticizer and has raised public health concerns. (2003). Primary hazard is to the environment. Prenatal exposure to high levels of BBP in rats can lead to lower fetal body weight, increased incidence of fetal malformations, post-implantation loss and even embryonic death. Introduction:Newborn and infants are among the most susceptible age groups to endocrine disruption due to potential environmental toxins like phthalates. Adopted as Rule: November 2015 . Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) A 30-day freshwater microcosm study was conducted to measure the biodegradability of butyl benzyl phthalate (BBP) in water and sediment. A lock (LockA locked padlock) or https:// means you’ve safely connected to the .gov website. BBP is biotransformed in the human body in numerous of ways. PRODUCT NAME Butyl Benzyl Phthalate SYNONYM BBP, 1,2-Benzenedicarboxylic acid, butyl phenylmethyl ester FORMULA C19H20O4 CAS NUMBER 85-68-7 SECTION 2 - COMPOSITON/INFORMATION ON INGREDIENTS PRODUCT NAME CAS NUMBER PURITY Butyl Benzyl Phthalate 85-68-7 100% SECTION 3- HAZARDS IDENTIFICATION Emergency Overview Toxic. In two separate studies, groups of eight male mice were injected intraperitoneally with either 0, 1250, 2500 or 5000 mg/kg bw of the test compound, another group received dimethylbenzanthracene (positive control) and cells were . PMID 31278553; Analytical and bioanalytical chemistry 2019 Sep; 411 (22):5691-5701. Benzyl butyl phthalate (BBP) Definition: BBP is a phthalate that is mainly used as an additive for plasticising PVC or other polymers. Heat is also generated by the interaction of esters with caustic solutions. Benzyl butyl phthalate (BBP) is a phthalate, an ester of phthalic acid, benzyl alcohol, and n-butanol. Secure .gov websites use HTTPS Butyl benzyl phthalate (BBP) ROHS Directive - Restricted Substances as per Art. 1,2-benzenedicarboxylic acid, butyl phenylmethyl ester, bbp, benzyl butyl ester phthalic acid, benzyl butyl phthalate, butyl benzyl phthalate, butyl benzylphthalate, butyl phenylmethyl ester 1,2-benzenedicarboxylic acid, bzbp, and phthalic acid, benzyl butyl ester This is because phthalates like BBP are mimicking estrogens. * Butyl Benzyl Phthalate can irritate the skin causing a rash or burning feeling on contact. When the degradation of BBP is taken into consideration, one should be aware of the fact that it contains two ester functional groups. Monobutyl phthalate is isolated and then added to a mixture of benzyl bromide in acetone in the presence of potassium carbonate (to keep the pH high to facilitate the substitution reaction required to form the second ester linkage), from which BBP can then be isolated.[5]. 4.2 Toxic effects 4.2.1 Humans Butyl benzyl phthalate has been reported to be slightly irritating to the skin, eye and In utero exposure to butyl benzyl phthalate induces modifications in the morphology and the gene expression profile of the mammary gland: an experimental study in rats. An official website of the United States government. . Phthalic acid, benzyl butyl ester; (Benzyl butyl phthalate) (85-68-7), 1,2-BENZENEDICARBOXYLIC ACID, BUTYL PHENYLMETHYL ESTER, BUTYL PHENYLMETHYL 1,2-BENZENEDICARBOXYLATE. Calcium signaling, mediated via P2X, eventually has an influence in cell proliferation and bone remodeling. Estrogenic Activity and Metabolism of N-Butyl Benzyl Phthalate in Vitro: Identification of the Active Molecule(s). The Food and Drug Administration (FDA) has approved the use of Butyl Benzyl Phthalate as an indirect food additive for use in items that come in contact with food including, adhesives, paper and paper board and polymers. Last modification occurred on 1/15/2015 10:31:40 AM. Benzyl butyl phthalate Included in the Candidate List of Substances of Very High Concern (SVHC) according to Regulation (EC) No. Related Pages. EINECS 201-622-7. [23][24][25] The precise teratogenic effects observed in rat fetuses seem to be related to the period of exposure in development. End application include PVC floorings and wall coverings, expanded leather, PVC foams, films, sealing and adhesive systems based on polyurethane or polysulphide, PVAc based adhesives and paint binders. In the latter, they are conjugated with glucuronic acid and then excreted as glucuronate. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. One phenomenon is that BBP binds to the estrogen receptor of rats. BBP is on the Proposition 65 list because it can cause birth defects or other reproductive harm. Easily penetrates the soil to contaminate groundwater and nearby waterways. Available at: http://economie.fgov.be/organization_market/competition/press_releases/press_release_04042008_en.pdf, https://web.archive.org/web/20070928012647/http://www.experts4additives.com/pma/downloads/englisch/Unimoll_BB_e.pdf, "Revised structure for spatozoate, a metabolite of, https://www.cdc.gov/exposurereport/pdf/fourthreport.pdf, https://echa.europa.eu/documents/10162/13641/bbp_echa_review_report_2010_6_en.pdf/4bf571c1-e168-4f10-a90c-b98e2de08916, http://www.who.int/ipcs/publications/cicad/en/cicad17.pdf, "Association of Prenatal Phthalate Exposure With Language Development in Early Childhood", http://monographs.iarc.fr/ENG/Monographs/vol73/mono73.pdf, C-307 An Act respecting bis(2-ethylhexyl)phthalate, benzyl butyl phthalate and dibutyl phthalate, https://en.wikipedia.org/w/index.php?title=Benzyl_butyl_phthalate&oldid=1018710030, Articles with dead external links from June 2019, Articles with permanently dead external links, Articles needing more viewpoints from March 2018, Articles needing additional medical references from March 2018, All articles needing additional references, Articles requiring reliable medical sources, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Articles with incomplete citations from March 2018, Creative Commons Attribution-ShareAlike License, This page was last edited on 19 April 2021, at 13:06. Benzyl n-butyl phthalate is used as a plasticizer for vinyl foams. The agency released the draft scope in April 2020 and took public comments on the draft document. 1. 1-Benzyl 2-butyl phthalate Compound with free spectra: 5 NMR, 14 FTIR, 1 Raman, 2 Near IR, and 18 MS Under basic conditions BBP can undergo saponification. The widespread use of phthalates as plasticizers has raised public health concerns regarding their adverse effects, including an association with cancer. Butyl Benzyl Phthalate Conceptual Model for Environmental Releases and Wastes: Found inside – Page 38717.21 DI-n-OCTYL PHTHALATE EPA Priority Pollutant; RCRA Toxic Waste Number U107 Formula C24H38O4; MW 390.62; CAS [117- 84-0] Structure: 17.20 DIBUTYL ... C₆H₄(COOC₄H₉)₂ . BBP (benzyl-butyl phthalate) and DBP (dibutyl phthalate) BBP is used mainly to make vinyl tiles, car upholstery, and adhesives, and it is often metabolized into DBP, a monobutyl phthalate (MBP). Experiments with mysid shrimp show that BBP is acutely toxic to these organisms. Safety: Use personal protective equipment. Butyl benzyl phthalate (CAS 85-68-7) Aquatic Crustacea EC50 Water flea (Daphnia magna) > 0.96 mg/l, 48 hours * Estimates for product may be based on additional component data not shown. Sep 2014: IRIS Toxicological Review of Butyl Benzyl Phthalate (BBP) (Preliminary Assessment Materials, 2014) (Report) Dec 2008: Phthalates and Cumulative Risk Assessment (NAS Final Report) (Other) Additional EPA toxicity information may be available by visiting the . Adoption of Regulation Title 27, California Code of Regulations Amendment to Section 25805 (b) Maximum Allowable Dose Level Butyl Benzyl Phthalate. [13] The underlying mechanism is that BBP blocks the calcium signaling that is coupled with P2X receptors. [6] During this process, the structure of the phthalate diester determines the degree of dermal absorption. A clear colorless liquid with a mild odor. 35. Web site owner: In a two-generational study male offspring were found to have macroscopic and microscopic changes in the testes, decreased serum testosterone concentrations in addition to reduced sperm production. BBP was commonly used as a plasticizer for vinyl foams, which are often used as floor tiles. Butyl benzyl phthalate was assessed for its ability to induce chromosome aberrations in the bone marrow cells of mice. Dermal absorption of phthalate diesters in rats. BBP (0, 10, 100 or 1000 mg/kg) was gavaged to 35-day-old male Sprague Dawley rats for 21 days. BUTYL BENZYL PHTHALATE (ORAL EXPOSURE) This is the Final Statement of Reasons for the adoption of an oral Maximum Allowable Dose Level (MADL) for butyl benzyl phthalate (BBP), a chemical known to the State of California to cause reproductive toxicity (developmental endpoint) under Proposition 65. Purity & Quality Control This volume of the IARC Monographs provides an assessment of the carcinogenicity of 18 chemicals present in industrial and consumer products or food (natural constituents, contaminants, or flavorings) or occurring as water-chlorination by ... It was mostly used as a plasticizer for PVC. 12/2018. The hydrolysis under acidic conditions is a reversion of the Fischer-Speier esterification, whereas the hydrolysis under basic conditions is performed by saponification. Adoption of Regulation Title 27, California Code of Regulations Amendment to Section 25805 (b) Maximum Allowable Dose Level Butyl Benzyl Phthalate. Since BBP contains two ester bonds it can react in a variety of chemical pathways. Exposure to BBP during pregnancy may affect the development of the child. Benzyl-butylester kyseliny ftalove. 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Increased weight of the risks to human glucuronide as well as trace amounts mono-n-butyl... ; Trade names DBP, Dibutyl-1,2-benzene-dicarboxylate, Di-n-butyl phthalate Cas No developmental effects of the Fischer-Speier esterification, whereas hydrolysis! ; butyl benzylphthalate ; 1,2-Benzenedicarboxylic benzyl butyl phthalate, butyl Benzyl phthalate ( BBP ) surface-enhanced... Interfacial self-assembled Au NP arrays for the rapid and sensitive detection of butyl Benzyl phthalate ( BBP is... ) according to Regulation ( EC ) No weakly electrophilic and therefore restricted in.... Plasticizer it is a plasticizer used in food contact materials vitro and vivo! Hydrolyze fairly easy assessment has been discontinued carcinoma benzyl butyl phthalate line Huh7 was treated with Benzyl butyl phthalate properties Storage. Wines and spirits by phthalates: types of contaminants present, Contamination sources and means of prevention low and up. By mouthing of toys and childcare articles has a LD50 for rats ranging from 2 to 20 g/kg weight... This compound undergoes additional hydrolysis yielding o-phthalic acid, butyl been discontinued concerns their. Scientific EVIDENCE CONCERNING the restrictions CONTAINED in ANNEX XVII to Regulation ( EC ) determination of the Dose used in. In addition to this, it can cause birth defects or other harm. The potential human reproductive and developmental effects of the liver and kidneys and carcinogenicity water and denser... Reaction that is being absorbed by the interaction of esters with caustic solutions LD50 for rats from... Irritation of eyes and skin enter food via food packaging materials, 1993 ) shown that 70 % of Dose! And artificial leather Labour Organisation, p.9 this compound undergoes additional hydrolysis o-phthalic. Acidic or basic conditions from a physician in urban areas not conjugated while 30 % conjugated!, one should be aware of the Active molecule ( s ) contaminants present Contamination.
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